Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonsecretory myeloma. A case report

H D Moehring

    Clinical Orthopaedics and Related Research
    |November 1, 1982
    PubMed
    Summary

    Nonsecretory myeloma, a rare plasma cell disorder, may be missed if doctors only look for M components. Diagnosis relies on bone lesions, anemia, and myeloma cells in bone marrow, not just protein levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Closed flexible intramedullary fixation for pathologic lesions in long bones.

    Orthopedics·2014
    Same author

    Surgical Implant Generation Network (SIGN) intramedullary nailing of open fractures of the tibia.

    International orthopaedics·2004
    Same author

    Comparison of antibiotic beads and intravenous antibiotics in open fractures.

    Clinical orthopaedics and related research·2000
    Same author

    Irreducible intertrochanteric fractures of the femur.

    Clinical orthopaedics and related research·1997
    Same author

    Removal of intramedullary nails from the femur: a review of 45 cases.

    Journal of orthopaedic trauma·1996
    Same author

    Compartment pressure monitoring during intramedullary fixation of tibial fractures.

    Orthopedics·1995

    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Plasma cell myelomatosis, or multiple myeloma, is typically diagnosed by detecting M components in serum or urine.
    • Nonsecretory myeloma is a rare subtype where M components are absent or undetectable.

    Observation:

    • This subtype may be overlooked due to reliance on traditional diagnostic markers.
    • Radiographic evidence often shows classic osteolytic bone lesions.
    • Laboratory findings can include anemia and hypogammaglobulinemia.

    Findings:

    • Diagnosis requires identifying myeloma cells in bone marrow aspirates.
    • Absence of detectable monoclonal immunoglobulin or Bence Jones protein on electrophoresis is key.
    • Osteolytic lesions and cytologically confirmed myeloma cells are crucial indicators.

    Implications:

    • Emphasizes the need for broader diagnostic criteria beyond M component detection.
    • Highlights the importance of bone marrow examination for diagnosing nonsecretory myeloma.
    • Aims to reduce diagnostic delays and improve patient outcomes for this rare condition.

    Related Experiment Videos