[Influence of catecholaminergic agents on the convulsant effect of corasol in rats]

It has been shown in experiments on rats that preinjection into the animals of amphetamine, isoprenaline hydrochloride, clonidine and phentolamine activating adrenergic transmission increases the resistance to the convulsant action of corasole. Disulfiram and guanethidine that decrease the content of noradrenaline in the body facilitate the development of corasole convulsions. The agents that change functional activity of the dopaminergic synapses (L-DOPA, alpha-methyldopa, apomorphine, perphenazine hydrochloride) exert no substantial effect on the convulsant effect of corasole. It is suggested that alpha- and beta-adrenergic structures participate in the mechanisms of catecholaminergic regulation of convulsant activity.