The possible role of reticulo endothelial system in hepatic regeneration

Calciphylactic blockade of Reticulo endothelial system (REB) was used to study the role of reticulo-endothelial system (RES) in hepatic regeneration. REB was induced by i.v. egg yolk administration in DHT sensitized animals, which were subsequently partially hepatectomized. Mitotic index and percentage regeneration were studied in these animals 48 hr after partial hepatectomy. REB produced a significant depression of the mitotic index and percentage regeneration in regenerating livers. This suggests that functional integrity of the RES in essential hepatic parenchymal proliferation after partial hepatectomy.