[Comparative studies on the healing of experimental gastric ulcers made at the angular incisure and subcardia]

Experimental gastric ulcers were prepared in dogs after the method by Hatafuku and Thal, one at the subcardia and the other at the angular incisure, and healing of these two ulcers were compared. After the operation, endoscopy was carried out at weekly intervals and the sites of ulcers were subjected to macroscopic and microscopic examinations for measuring the ratio of epithelization. The healing of experimental ulcers was also examined under the conditions either with ligation or embolization of the left and right gastric arteries. The results obtained are summarized as follows. 1) Ten dogs with ulcer preparation only showed 3 persistent and 7 perforated ulcers at the subcardia and 4 healed, 4 persistent and 2 perforated ulcers at the angular incisure. 2) Four dogs with vessel ligation showed 2 persistent and 2 perforated ulcers at the subcardia and 1 healed, 2 persistent and 1 perforated ulcers at the angular incisure. 3) In 6 dogs with vessel embolization, 3 showed regional erosions. 4) The ratio of epithelization were 23.3% for the high and 68.2% for the low ulcers in the dogs with ulcer preparation only, while these were 11.3% and 54.5% respectively for the dogs with vessel ligation. In conclusion, the healing of high gastric ulcers were consistently inferior to the one of low gastric ulcers in every preparation. The cause of poor healing of the high gastric ulcers may be elucidated both by the circulatory disturbance and hypermotility of the ulcer region.