Hyperalgesia induced by non-noxious stress in the rat

Stress-induced analgesia is well known but the reverse phenomenon is poorly documented. In this work, hyperalgesia is described following stressful but non-noxious manipulations consisting of inescapable holding or exposure to a novel environment. Hypophysectomy (HX) and dexamethasone enhanced 'holding' hyperalgesia. In contrast, 'novelty' hyperalgesia was reduced by HX and not modified by dexamethasone. So, pituitary factors may respectively compensate and take part in stress hyperalgesia. Thus pain can be modulated in opposite directions by different types of stimulation: hyperalgesia would predominate after moderate, anxiogenic stress and analgesia after noxious and/or intense stress.