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Angioneurotic oedema in the elderly
Scottish Medical Journal
|October 1, 1982
Summary
Hereditary angioneurotic oedema (HANO) can present with severe abdominal crises. Successful treatment was achieved using ethinyltestosterone (Danazol), significantly improving the patient's quality of life.
Area of Science:
- Medical Genetics
- Immunology
- Gastroenterology
Background:
- Hereditary angioneurotic oedema (HANO) is a rare genetic disorder.
- Characterized by recurrent episodes of swelling in various body parts.
- Abdominal crises, including bilious vomiting and severe pain, are a common manifestation.
Observation:
- A 72-year-old patient reported a 60-year history of debilitating abdominal crises.
- Symptoms were described as 'bilious vomiting or migraine'.
- Detailed clinical and family history pointed towards HANO.
Findings:
- Complement studies confirmed the diagnosis of hereditary angioneurotic oedema.
- Treatment with oral ethinyltestosterone (Danazol) was initiated at 600 mg/day.
- The dosage was successfully reduced to 200 mg/day, completely abolishing attacks.
Implications:
- Early and accurate diagnosis of HANO is crucial for effective management.
- Ethinyltestosterone (Danazol) is an effective treatment for HANO-related abdominal crises.
- Long-term management can significantly improve patient outcomes and quality of life.