Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary cholesterol in cancer screening

D Jüngst, M Osterholzer, R Tauber

    Urology
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The need for cardiac surgery differential tariffs in Israel at the era of aging population and emerging technology: Importance of procedure type and patient complexity as assessed by EuroSCORE.

    Israel journal of health policy research·2021
    Same author

    [Bone-specific therapy with radium-223 dichloride : Castration-resistant prostate cancer with symptomatic bone metastases].

    Der Urologe. Ausg. A·2017
    Same author

    [PSMA-targeted radioligand therapy in prostate cancer].

    Der Urologe. Ausg. A·2016
    Same author

    [Not Available].

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
    Same author

    [Antegrade scrotal sclerosis therapy. Gold Standard of varicocele treatment].

    Der Urologe. Ausg. A·2015
    Same author

    Neurofibromatosis involving the left labium majus of a colored patient.

    The Urologic and cutaneous review·2010

    Urinary cholesterol screening for microscopic hematuria shows high accuracy for detecting urologic cancer. This simple test can identify patients needing further investigation for urinary tract malignancies.

    Area of Science:

    • Urology
    • Biochemistry
    • Oncology

    Background:

    • Microscopic hematuria is a common finding requiring investigation for underlying urologic conditions.
    • Current diagnostic methods can be invasive or costly, necessitating simpler screening tools.

    Purpose of the Study:

    • To evaluate the utility of urinary cholesterol levels as a non-invasive screening biomarker for urologic malignancies in patients with microscopic hematuria.
    • To compare urinary cholesterol excretion in patients with urologic cancer, benign kidney diseases, urinary tract infections, and healthy individuals.

    Main Methods:

    • Collected morning urine samples from 235 patients with microscopic hematuria.
    • Measured urinary cholesterol using a colorimetric assay.
    • Analyzed cholesterol levels in relation to diagnosed urologic malignancies, benign conditions, and healthy controls.

    Related Experiment Videos

    Main Results:

    • Significantly elevated urinary cholesterol levels were observed in patients with urologic malignancies (median 5.5 mg) compared to those with benign diseases (median 1.1 mg) or no urinary disorders (median 0.35 mg).
    • A cutoff of 1.0 mg urinary cholesterol per morning urine demonstrated approximately 80% sensitivity and 90% specificity for detecting urologic carcinomas.
    • Colorimetric determination of urinary cholesterol proved effective and simpler than gas-liquid chromatography.

    Conclusions:

    • Urinary cholesterol measurement is a promising, cost-effective screening tool for identifying urologic malignancies in patients presenting with microscopic hematuria.
    • This biomarker can effectively stratify patients into high and low prevalence groups for urologic cancer, guiding further diagnostic workups.
    • The colorimetric assay for urinary cholesterol is recommended for screening populations with microscopic hematuria.