Assessment of left ventricular function by resting and exercise radionuclide angiocardiography following acute...

Left ventricular function was evaluated by first-pass radionuclide angiocardiography in 42 patients at 3 and 8 weeks following acute myocardial infarction. Left ventricular ejection fraction, diastolic volume, and wall motion were measured at rest and submaximal exercise at 3 weeks and at rest, submaximal and maximal exercise at 8 weeks. The mean ejection fraction, end-diastolic volume, and wall motion index did not change between 3 and 8 weeks in any group either at rest or during submaximal exercise. Ventricular function was decreased at rest in patients with previous and anterior myocardial infarctions, but not in patients with inferior and subendocardial myocardial infarctions. During maximal exercise at 8 weeks, nine patients (21%) had ST segment depression, whereas 25 patients (60%) had a decrease in ejection fraction or a deterioration in wall motion. These abnormalities of ventricular function during exercise occurred equally among the infarct groups. Radionuclide angiography in patients with recent myocardial infarction demonstrated highly variable ventricular function at rest and/or during exercise in each infarct subgroup.