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Related Experiment Videos

The irreversibly sickled cell

C M Smith, W Krivit, J G White

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Irreversibly sickled cells (ISC) in sickle cell anemia may cause vaso-occlusion, but their exact role remains unclear. Heterogeneity in ISC physical properties suggests a specific subpopulation might be key, though not identifiable on blood smears.

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    Area of Science:

    • Hematology
    • Cell Biology
    • Disease Pathophysiology

    Background:

    • Sickle cell anemia is characterized by irreversibly sickled cells (ISC).
    • ISC are linked to reduced red blood cell survival but not directly to sickle crisis severity.
    • The physical properties of ISC are heterogeneous, suggesting varied functional roles.

    Purpose of the Study:

    • To review the characteristics of ISC.
    • To explore the potential significance of ISC in sickle cell vaso-occlusion.
    • To investigate the heterogeneity of ISC physical properties, particularly deformability.

    Main Methods:

    • Review of existing literature on irreversibly sickled cells.
    • Analysis of ISC deformability and physical properties.

    Related Experiment Videos

  • Filtration-based separation of ISC subpopulations.

    • Main Results:

    • ISC exhibit heterogeneous physical properties, indicating potential subpopulations.
    • Filtration-separated 'hard' ISC share morphological and intracellular characteristics with 'soft' ISC.
    • These differences in ISC are not discernible through standard blood smear examination.

    Conclusions:

    • The heterogeneity of ISC suggests a specific subpopulation may disproportionately contribute to vaso-occlusion.
    • Despite differences in deformability, distinct ISC subpopulations are not easily identified morphologically.
    • Further research is needed to elucidate the precise role of ISC subpopulations in sickle cell disease pathophysiology.