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Bronchial hyperreactivity in chronic obstructive bronchitis

J W Ramsdell, F J Nachtwey, K M Moser

    The American Review of Respiratory Disease
    |November 1, 1982
    PubMed
    Summary
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    Patients with chronic obstructive bronchitis exhibit airway hyperreactivity, contributing to exacerbations even without bronchodilator response. This suggests prophylactic bronchodilator therapy may benefit these individuals.

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Chronic obstructive bronchitis patients experience acute exacerbations.
    • Episodic bronchoconstriction is a potential factor in disease progression.

    Purpose of the Study:

    • To evaluate the incidence of bronchial hyperreactivity in chronic obstructive bronchitis patients.
    • To assess the role of airway hyperreactivity in exacerbations.

    Main Methods:

    • Methacholine bronchial provocation tests were used.
    • 22 patients with chronic obstructive bronchitis and no sympathomimetic response were studied.
    • Asthma patients were excluded.

    Main Results:

    • All patients showed significant baseline airway obstruction.

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  • No improvement in pulmonary function was observed after isoproterenol inhalation.
  • All patients demonstrated significant sensitivity to methacholine.

    • Conclusions:

    • Airway hyperreactivity may contribute to acute exacerbations in chronic obstructive bronchitis.
    • Prophylactic bronchodilator therapy may be warranted.
    • Hyperreactivity exists independently of acute bronchodilator reversibility.