Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms in manic-depressive disorder: an evolutionary model

R Gardner

    Archives of General Psychiatry
    |December 1, 1982
    PubMed
    Summary

    Mania and depression may mirror social hierarchies in animal groups, suggesting bipolar disorder states are linked to social rank and potentially genetically influenced. This model offers insights into manic-depressive disorder research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The XENONnT dark matter experiment.

    The European physical journal. C, Particles and fields·2024
    Same author

    Non-oral manifestations in adults with a clinical and molecularly confirmed diagnosis of periodontal Ehlers-Danlos syndrome.

    Frontiers in genetics·2023
    Same author

    Search for New Physics in Electronic Recoil Data from XENONnT.

    Physical review letters·2022
    Same author

    How do you determine the optimal biologic treatment for psoriasis?

    The British journal of dermatology·2019
    Same author

    First Dark Matter Search Results from the XENON1T Experiment.

    Physical review letters·2017
    Same author

    Voluntary premarital screening to prevent sickle cell disease in Jamaica: does it work?

    Journal of community genetics·2017

    Area of Science:

    • Behavioral Neuroscience
    • Psychiatry
    • Comparative Psychology

    Background:

    • Manic characteristics resemble dominant "alpha" social behaviors.
    • Depressive characteristics resemble subordinate "omega" social behaviors.

    Purpose of the Study:

    • To propose a theoretical model of manic-depressive disorder (bipolar disorder).
    • To hypothesize that bipolar states are linked to social rank.
    • To explore genetic transmission and state-specific mechanisms.

    Main Methods:

    • Comparative analysis of human manic-depressive symptoms and animal social hierarchies.
    • Theoretical modeling of bipolar states in relation to social rank.
    • Hypothesizing genetic transmission mechanisms.

    Main Results:

    • Manic-depressive states may be variations of normal organismic states tied to social rank extremes.
    • These states are easily triggered and rigidly maintained, diverging from social reality.
    • Genetic mechanisms are presumed to facilitate onset and maintenance.

    Conclusions:

    • Bipolar disorder components can be viewed as variations of normal states, pathological, or reactive.
    • The proposed model may guide future research, including studies with experimental animals.
    • This framework integrates social behavior, genetics, and psychiatric conditions.

    Related Experiment Videos