[Development of chronic experimental (acetate) ulcer of the duodenum in rats following vagotomy]

Morphogenesis of a chronic acetate-induced duodenal ulcer (in S. Okabe modification) has been studied in male rats for 4.5 months. Five stages have been revealed in the ulcer development: tissue necrobiosis and necrosis (1-3 days), rejection of the necrotic masses (3-5 days), outgrowth of the connective tissue in the fundus of the ulcer (5-13 days), reduction of the connective tissue and completion of epithelization (13-40 days), the mucosal tunic formation at the place of the ulcer (40-137 days). Bilateral subdiaphragmal vagotomy performed both before (11 days earlier) and after (10 days after) the ulcer induction positively affects the process of its spontaneous healing, but is accompanied with certain disorders in formation processes in the ulcer area: the newly formed villi are of smaller height and have irregular form, the newly formed duodenal glands are more often subjected to cystic dilatation.