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Related Experiment Videos

Cimetidine does not alter morphine disposition in man

P Mojaverian, I L Fedder, P H Vlasses

    British Journal of Clinical Pharmacology
    |December 1, 1982
    PubMed
    Summary
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    Cimetidine did not alter morphine pharmacokinetics or its pupil-constricting effects in healthy volunteers. This suggests cimetidine does not significantly reduce liver blood flow.

    Area of Science:

    • Pharmacology
    • Drug Metabolism
    • Clinical Pharmacology

    Background:

    • Morphine is a widely used analgesic.
    • Cimetidine is a medication that can affect drug metabolism.
    • Understanding drug interactions is crucial for patient safety.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between cimetidine and morphine.
    • To determine if cimetidine affects morphine's plasma clearance, volume of distribution, AUC, or half-life.
    • To assess the impact of cimetidine on morphine-induced miosis.

    Main Methods:

    • A crossover study design was employed.
    • Participants received either cimetidine (300 mg every 6 hours) or placebo for 4 days.
    • Pharmacokinetic parameters of morphine were measured.

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  • Morphine-induced miosis was assessed.

    • Main Results:

    • Cimetidine did not significantly alter morphine's plasma clearance, volume of distribution, AUC, or half-life.
    • No significant effect of cimetidine was observed on the magnitude or duration of morphine-induced miosis.
    • Statistical analysis showed P > 0.05 with power > 0.80 for these findings.

    Conclusions:

    • Cimetidine does not appear to affect the pharmacokinetics of morphine in healthy volunteers.
    • The lack of effect on morphine, a high extraction ratio drug, suggests cimetidine does not significantly reduce hepatic blood flow.
    • These findings indicate a low likelihood of significant pharmacokinetic interaction between cimetidine and morphine in this population.