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Decreased deformability in aging erythrocytes

G Bartosz, J Niewiarowska, L Judkiewicz

    Biochimica Et Biophysica Acta
    |December 8, 1982
    PubMed
    Summary
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    Youngest and oldest bovine erythrocytes show reduced deformability compared to middle-aged cells. This finding suggests cell deformability may not be the primary factor in removing aged red blood cells from circulation.

    Area of Science:

    • Hematology
    • Cell Biology
    • Biophysics

    Background:

    • Erythrocyte senescence involves changes in cell properties.
    • The role of erythrocyte deformability in the clearance of aged cells is debated.

    Purpose of the Study:

    • To investigate the relationship between erythrocyte age and deformability in cattle.
    • To assess the contribution of deformability to the recognition and removal of senescent erythrocytes.

    Main Methods:

    • Bovine erythrocytes were separated by density, correlating with age.
    • Deformability was measured using a modified Teitel's filterability test.
    • Additional assessments included the Sirs centrifugational test and cell suspension viscosity measurements.

    Main Results:

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    • Both the youngest and oldest erythrocyte populations exhibited lower deformability.
    • Middle-aged erythrocytes demonstrated the highest deformability.
    • These age-related deformability changes were observed across multiple measurement techniques.

    Conclusions:

    • Erythrocyte deformability in cattle varies with cell age.
    • The reduced deformability of both young and old erythrocytes challenges the hypothesis that deformability is the main signal for senescent cell removal.
    • Further research is needed to elucidate the mechanisms of erythrocyte clearance.