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Related Experiment Videos

Albumin concentration in normal and pathological human thyroids

M Netto, D Rosenthal

    Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
    |July 1, 1982
    PubMed
    Summary

    Thyroid albumin concentration increases in pathological thyroid tissues, particularly in papillary carcinomas and Hashimoto's thyroiditis. Most extravascular albumin is within the thyroid follicle, indicating a significant rise in thyroid disorders.

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    Area of Science:

    • Endocrinology
    • Biochemistry
    • Pathology

    Background:

    • Thyroid albumin is a protein found in thyroid tissue.
    • Understanding its concentration in normal versus pathological conditions is crucial for diagnosing thyroid disorders.
    • Previous studies have not fully elucidated the distribution and concentration of extravascular thyroid albumin.

    Purpose of the Study:

    • To quantify and compare the concentration of extravascular thyroid albumin in normal and pathological human thyroid tissues.
    • To investigate the in vivo labeling of thyroid albumin using Iodine-125 (125I).
    • To explore the relationship between albumin and thyroglobulin concentrations in various thyroid conditions.

    Main Methods:

    • Human thyroid tissue specimens (N=54) from normal and pathological conditions were analyzed.

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  • Saline-soluble proteins were fractionated using Sephadex G-200 gel filtration.
  • Intravascular albumin was calculated based on hemoglobin and hematocrit values, with extravascular albumin determined by subtraction.

    • Main Results:

    • Extravascular albumin concentration was significantly lower in normal thyroid tissue (14.9 mg/g) compared to adenomas, papillary carcinomas (51.1 mg/g), and Hashimoto's thyroiditis.
    • In vivo 125I labeling confirmed the presence and distribution of albumin within the thyroid tissue.
    • The ratio of radioactivity (albumin/thyroglobulin) was significantly higher in pathological tissues than in normal tissues.

    Conclusions:

    • The majority of extravascular thyroid albumin is located within the thyroid follicle.
    • A significant increase in extravascular thyroid albumin concentration is associated with various thyroid disorders.
    • These findings highlight albumin as a potential biomarker in thyroid pathology.