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Updated: Jul 24, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Schizophrenia and suicide in a north Swedish isolate, 1890-1980
Abstract:
The epidemiological and genetic investigation of schizophrenic psychoses over the period 1900-1978 which has been carried out in a specified North Swedish geographical isolate was supplemented with a study of suicides. For the period 1890-1980, a total of 90 suicides have been ascertained. Of these, 54 had at least one schizophrenic relative at a maximum genetic distance of 1/8, while 11 had schizophrenic relatives further removed. It is likely that at least some of these suicides were manifestations of acute and/or undiagnosed psychoses. Thus the previously reported high general morbid risk of schizophrenia in this population (2.7%) would be a rather conservative estimate. On the other hand, the findings would not appreciably change the morbid risk for first-degree relatives of schizophrenic probands.
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