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Updated: Oct 9, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
Published on: October 19, 2011
[Neurotic triad and change in blood platelet number in reaction to stress]
Insights
Psychological stress impacts blood platelet counts differently in individuals. Non-coronary subjects with lower psychological distress showed reduced platelet counts compared to other groups.
Area of Science:
- Cardiology
- Psychology
- Hematology
Background:
- Catheterization procedures can induce physiological stress.
- Psychological factors may influence hematological parameters like platelet count.
Purpose of the Study:
- To investigate the relationship between psychological profiles and blood platelet count changes following catheterization stress.
- To compare platelet responses in myocardial infarction patients versus non-coronary subjects.
Main Methods:
- Blood platelet counts were measured three times in response to catheterization stress.
- Participants (21 myocardial infarction patients, 21 non-coronary subjects) were categorized based on psychological scale results (hypochondria, depression, hysteria via M.M.P.I.).
Main Results:
- Non-coronary subjects with low scores on hypochondria, depression, and overall psychological scales exhibited lower platelet counts.
- Non-coronary subjects with high psychological scores had similar platelet counts to coronary patients, regardless of their psychological score.
Conclusions:
- Psychological distress levels appear to modulate blood platelet count responses to stress in non-coronary individuals.
- Platelet count reactivity to catheterization stress may be influenced by psychological state, particularly in healthy individuals.
Abstract:
Blood platelet count is evaluated three times in reaction to catheterization stress in a group of 21 myocardial infarction patients and a group of 21 non-coronary subjects. Coronary and non-coronary patients are divided in two groups according to their low or high results at the psychological scales (hypochondria, depression, hysteria of the M.M.P.I.). The group of non-coronary patients with low results in hypochondria, depression and in the sum of the three psychological scales presents a lower platelet count than the other groups. The non-coronary subjects with high psychological results have the same platelet count as the coronary patients with high or low values.
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