[Neurotic triad and change in blood platelet number in reaction to stress]

L'Encephale
|January 1, 1982
PubMed

Insights

Psychological stress impacts blood platelet counts differently in individuals. Non-coronary subjects with lower psychological distress showed reduced platelet counts compared to other groups.

Area of Science:

  • Cardiology
  • Psychology
  • Hematology

Background:

  • Catheterization procedures can induce physiological stress.
  • Psychological factors may influence hematological parameters like platelet count.

Purpose of the Study:

  • To investigate the relationship between psychological profiles and blood platelet count changes following catheterization stress.
  • To compare platelet responses in myocardial infarction patients versus non-coronary subjects.

Main Methods:

  • Blood platelet counts were measured three times in response to catheterization stress.
  • Participants (21 myocardial infarction patients, 21 non-coronary subjects) were categorized based on psychological scale results (hypochondria, depression, hysteria via M.M.P.I.).

Main Results:

  • Non-coronary subjects with low scores on hypochondria, depression, and overall psychological scales exhibited lower platelet counts.
  • Non-coronary subjects with high psychological scores had similar platelet counts to coronary patients, regardless of their psychological score.

Conclusions:

  • Psychological distress levels appear to modulate blood platelet count responses to stress in non-coronary individuals.
  • Platelet count reactivity to catheterization stress may be influenced by psychological state, particularly in healthy individuals.

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...