Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor dysfunction in spontaneous thymoma rats, Buffalo/Mna

F Kato, M Watanabe

    Journal of Pharmacobio-Dynamics
    |September 1, 1982
    PubMed
    Summary

    Spontaneous thymoma in Mna rats causes muscle weakness and fatigability due to impaired muscle contractile mechanisms. Reduced curare sensitivity suggests neuro-muscular junction alterations in these rats.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gastrointestinal: Solid pseudopapillary neoplasm of the pancreas with high-grade malignant transformation.

    Journal of gastroenterology and hepatology·2024
    Same author

    PREVALENCE AND INCIDENCE OF FOUR COMMON BEAN ROOT ROTS IN UGANDA.

    Experimental agriculture·2020
    Same author

    Phage-inactivating Effect of Iron(II)-Ascorbate Complex.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Effects of Microorganisms on the Peroxidation of Lipid and Fatty Acid Composition of Fermented Fish Meal.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Dysgammaglobulinemia Associated With Glu349del, a Hypomorphic XIAP Mutation.

    Journal of investigational allergology & clinical immunology·2015
    Same author

    Observation of the (Λ)(7)He hypernucleus by the (e, e'K+) reaction.

    Physical review letters·2013

    Area of Science:

    • Neuroscience
    • Muscle Physiology
    • Pharmacology

    Background:

    • Spontaneous thymoma in Buffalo/Mna rats leads to observable muscle weakness and fatigability.
    • Understanding the underlying mechanisms of muscle dysfunction in Mna rats is crucial for potential therapeutic interventions.

    Purpose of the Study:

    • To investigate the in vivo electrophysiological and pharmacological properties of muscle responsiveness in Mna rats.
    • To determine the principal cause of muscle weakness and fatigability in Mna rats.

    Main Methods:

    • In vivo electrophysiological recordings of hindlimb muscle responses to nerve stimulation.
    • Pharmacological testing using curare and 4-aminopyridine to assess drug sensitivity.
    • Comparative analysis between Mna rats and control ACI rats.

    Main Results:

    • Mna rats exhibited reduced muscle contractility and increased fatigability compared to ACI rats.
    • No significant difference in the time course of evoked electromyogram amplitudes was observed.
    • Mna rats showed significantly reduced sensitivity to curare, while sensitivity to 4-aminopyridine remained normal.

    Conclusions:

    • Mna rats demonstrate increased muscle fatigability and weakness.
    • The primary cause appears to involve contractile mechanisms beyond the muscle cell membrane.
    • Diminished curare sensitivity points towards potential alterations at the neuro-muscular junction.

    Related Experiment Videos