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Related Experiment Videos

Lung split function test and pneumonectomy. A lower limit for operability

K H Tønnesen, H Dige-Petersen, J O Lund

    Scandinavian Journal of Thoracic and Cardiovascular Surgery
    |January 1, 1978
    PubMed
    Summary
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    Regional 133Xe ventilation/perfusion studies accurately predict lung function after pulmonary resections. Perfusion studies alone reliably forecast postoperative outcomes, preventing permanent disability in lung cancer patients.

    Area of Science:

    • Pulmonary Medicine
    • Radiology
    • Surgical Oncology

    Background:

    • Pulmonary resections for cancer can lead to significant postoperative lung function impairment.
    • Accurate prediction of residual lung function is crucial for patient selection and management.

    Purpose of the Study:

    • To evaluate the accuracy of 133Xe ventilation/perfusion (V/Q) studies in predicting lung function after pulmonary resections.
    • To assess the clinical outcomes of patients undergoing pulmonary resection for cancer with impaired lung function.

    Main Methods:

    • Regional 133Xe V/Q scintigraphy was employed to estimate postoperative lung function.
    • Predicted postoperative maximal breathing capacity (MBC) was calculated.
    • Postoperative spirometry was used to validate the predictions in a subset of patients.

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  • Perfusion-only studies were compared with combined V/Q studies.

    • Main Results:

    • The V/Q study method demonstrated good accuracy in predicting postoperative lung function.
    • Predicted MBC values ranged from 17 to 41 l/min-1 m-2 in 25 patients with impaired lung function.
    • No patients experienced permanent pulmonary invalidism.
    • One patient died from myocardial infarction, 7 had transient pulmonary insufficiency, and 17 recovered without complications.
    • Perfusion studies alone were as reliable as combined V/Q studies for outcome prediction.

    Conclusions:

    • 133Xe V/Q scintigraphy is a reliable tool for predicting residual lung function after pulmonary resection.
    • Perfusion imaging alone is sufficient for predicting postoperative outcomes.
    • Surgical intervention in selected patients with impaired lung function and pulmonary cancer can be performed with acceptable morbidity and mortality rates.