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Updated: Aug 19, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Cell-mediated immunity in normal pregnancy and pre-eclampsia
Abstract:
The in vitro responses of maternal lymphocytes to phytohaemagglutinin (PHA), concanavalin A (Con A) and purified protein derivative of tuberculin (PPD) were determined in uncomplicated and pre-eclamptic pregnancies and nongravid female controls. PHA, Con A and PPD responses were significantly lower in both pregnant groups compared to nongravid controls. No difference was observed in lymphocyte reactivity between women with pre-eclampsia or uncomplicated pregnancy. Both pregnant groups exhibited normal numbers of circulating T and B lymphocytes. The number of active E rosette-forming cells was significantly higher in peripheral blood of pre-eclamptic patients.
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