Jove
Visualize
Contact Us

Related Experiment Videos

Nasal dermal sinuses--new concepts and explanations

R B Sessions

    The Laryngoscope
    |August 1, 1982
    PubMed
    Summary

    Nasal dermal sinus cysts (NDSC) have a consistent pathogenesis, with intracranial involvement predictable via characteristic skull base deformities identifiable on imaging. This study confirms embryonic pathways, aiding surgical planning for NDSC.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.

    The Biochemical journal·2015
    Same author

    Protein engineering applications of industrially exploitable enzymes: Geobacillus stearothermophilus LDH and Candida methylica FDH.

    Biochemical Society transactions·2007
    Same author

    Amino acid pairing preferences in parallel beta-sheets in proteins.

    Journal of molecular biology·2005
    Same author

    Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus.

    Molecular and biochemical parasitology·2003
    Same author

    Protochlorophyllide oxidoreductase: a homology model examined by site-directed mutagenesis.

    Proteins·2001
    Same author

    Planned neck dissection for advanced primary head and neck malignancy treated with organ preservation therapy: disease control and survival outcomes.

    Head & neck·2001
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Embryopathology
    • Craniofacial development
    • Neurocristopathies

    Background:

    • Nasal dermal sinus cysts (NDSC) are congenital anomalies requiring precise understanding for effective management.
    • Previous studies speculated on NDSC pathogenesis and intracranial extension, but lacked definitive embryologic correlation.

    Observation:

    • A study of 13 NDSC patients, including 4 with intracranial involvement, correlated preoperative imaging with surgical findings.
    • Embryologic studies in human embryos identified a neuroectodermal pathway through the prenasal space.

    Findings:

    • NDSC pathogenesis is consistent, with intracranial extension predictable by characteristic skull base deformities visible radiographically.
    • Embryologic evidence confirms a pathway for dermal displacement through the prenasal space into the foramen cecum.
    • The study demonstrates an anatomic basis for intracranial dermal cyst growth within the falx cerebri.

    Implications:

    • A protocol for identifying intracranial extension of NDSC based on radiographic findings can guide surgical planning.
    • NDSC may represent one disorder within a spectrum of neurocristopathies involving dermal, neural displacement, and cranial floor deformities.
    • Understanding embryologic pathways enhances diagnostic accuracy and treatment strategies for congenital midline nasal masses.

    Related Experiment Videos