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[Intracranial aneurysm and polycystic kidneys]
Neuro-Chirurgie
|January 1, 1982
Summary
Polycystic kidney disease is associated with intracranial aneurysms in a notable percentage of cases. Surgical outcomes for these aneurysms are comparable to those without polycystic kidney disease, suggesting a potential congenital link.
Area of Science:
- Neurology
- Nephrology
- Vascular Surgery
Background:
- Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys.
- Intracranial aneurysms are abnormal balloon-like bulges in the blood vessels of the brain.
- The co-occurrence of PKD and intracranial aneurysms is a recognized clinical association, necessitating careful screening and management.
Observation:
- This report details five cases of patients presenting with both intracranial aneurysms and polycystic kidneys.
- Prevalence data indicates that approximately 15% of individuals with PKD have an intracranial aneurysm, and 4%-5% of intracranial aneurysms occur in patients with PKD.
Findings:
- Surgical intervention for intracranial aneurysms in patients with co-existing polycystic kidneys does not appear to carry a significantly higher risk compared to patients without PKD.
- The surgical prognosis for intracranial aneurysms associated with PKD is generally favorable, with no indication of worse outcomes.
Implications:
- The pathogeny of this association remains unclear, but it may stem from a shared congenital defect in the elastic system of blood vessels.
- Further research into the underlying mechanisms of this association is warranted to improve preventative strategies and treatment protocols for affected individuals.