Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular aspects of granulomas

H Cain, B Kraus

    Pathology, Research and Practice
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Granulomas in sarcoidosis and thyroiditis share organizational features, with distinct central and outer zones. Giant cells show ordered structures indicating function or exhaustion, and epithelioid cells are highly secretory.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    North of England Women's Diet and ActivitY - After Breast Cancer (NEWDAY-ABC) intervention in women diagnosed with early oestrogen-positive, HER2-negative breast cancer: a randomised controlled feasibility study.

    Pilot and feasibility studies·2025
    Same author

    Corrigendum to "User evaluation of clinical simulation-based learning developed by FORCE (Framework for Online Radiographer Clinical Education)"[Radiography 31 (2025)].

    Radiography (London, England : 1995)·2025
    Same author

    Professional challenges faced by student radiographers during COVID-19.

    Radiography (London, England : 1995)·2025
    Same author

    Multi-omics driven genome-scale metabolic modeling improves viral vector yield in HEK293.

    Metabolic engineering·2025
    Same author

    User evaluation of clinical simulation-based learning developed by FORCE (Framework for Online Radiographer Clinical Education).

    Radiography (London, England : 1995)·2025
    Same author

    Ultrasound education across European Federation of Radiographers Societies (EFRS) countries: Similarities and differences.

    Radiography (London, England : 1995)·2024

    Area of Science:

    • Cell biology
    • Pathology
    • Immunology

    Background:

    • Granulomas are organized inflammatory structures found in various diseases.
    • Understanding granuloma cellular composition and organization is crucial for diseasepathology.
    • Previous studies have described different cell types within granulomas, but their functional relationships remain unclear.

    Purpose of the Study:

    • To investigate the common organizational features of human granulomas (sarcoidosis, de Quervain's thyroiditis) and experimental rat granulomas.
    • To elucidate the functional roles and interrelationships of different cell types within granulomas, including epithelioid cells and giant cells.

    Main Methods:

    • Comparative morphological investigation of human and experimental granulomas.
    • Analysis of cellular composition, including epithelioid cells, macrophages, lymphocytes, and giant cells.

    Related Experiment Videos

  • Microscopic examination of intercellular contacts, cytoskeleton, and organelle distribution within cells.

    • Main Results:

    • Granulomas exhibit a common organization with a central zone (epithelioid cells, macrophages, lymphocytes) and an outer transitional zone (macrophages, necrotic elements).
    • Multinucleate giant cells (Langhans type) display ordered structures, suggesting functional activity (lightly stained) or exhaustion (darkly stained).
    • Epithelioid cells possess a prominent secretory apparatus and cytoskeleton involvement in degranulation, potentially leading to necrosis.

    Conclusions:

    • Despite differing cellular compositions, granulomas share fundamental organizational principles.
    • The observed structures of giant cells and epithelioid cells suggest distinct functional states and dynamic processes within granulomas.
    • The study proposes that described subtypes of epithelioid cells represent different stages of a single cell type.