[A and B apoproteins and serum lipids in clinically healthy males]

Serum levels of total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), Apoprotein A (Apo A) and Apoprotein B (Apo B) were determined in 125 healthy male subjects (bank clerks), aged 20-59 years, in order to screen risk factors of atherosclerosis (ATS) in our population. TC, TG, LDL-C and Apo B increase with aging, while HDL-C and Apo A do not. HDL-C correlates inversely with LDL-C, Apo B ad TG and positively with Apo A. LDL-C, TC and TG show a positive correlation with Apo A. Weight index, cigarette smoking, systolic blood pressure (SBP) negatively affect HDL-C levels which present a positive relation with alcohol intake. Apo B, TC and TG are, moreover, significantly increased by smoking and body weight. A multiple linear regression analysis choosing HDL-C and Apo B as dependent variables indicates that Apo A, TG, SBP, age and alcohol consumption are the attributes mostly associated with HDL-C while TC, smoking, Apo A and SBP are the independent variables which best explain total variance of Apo B. It is worth noting, in this respect, the effect of smoking on Apo B: such a result could provide a further explanation of the well-known connection between smoking and ATS.