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[Clofibrate therapy--current status from a gerontological viewpoint]

W Reuter

    Zeitschrift Fur Alternsforschung
    |September 1, 1982
    PubMed
    Summary

    Clofibrate effectively treats hyperlipoproteinemia by managing triglyceride and cholesterol levels, reducing heart disease risks. However, potential side effects like gallstones necessitate careful patient selection for this metabolic disorder treatment.

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    Area of Science:

    • Metabolic Disorders
    • Cardiovascular Health
    • Pharmacology

    Context:

    • Hyperlipoproteinemias are prevalent metabolic disorders in aging populations, contributing significantly to atherogenesis.
    • Effective management of these lipid metabolism disturbances is crucial for preventing cardiovascular complications.
    • Clofibrate, with clofibrinic acid as its active substance, is a widely used therapeutic agent for hyperlipoproteinemia.

    Purpose:

    • To summarize the current understanding of clofibrate therapy for hyperlipoproteinemia, including its effects and side effects.
    • To outline the therapeutic applications and indications for clofibrate treatment based on epidemiological evidence and clinical studies.

    Summary:

    • Clofibrate primarily impacts triglyceride metabolism and secondarily affects cholesterol metabolism.
    • Epidemiological studies indicate clofibrate's efficacy in reducing coronary morbidity and mortality.
    • A known side effect of clofibrate therapy is an increased incidence of cholelithiasis (gallstones).

    Impact:

    • Clofibrate is indicated for hypertriglyceridemias (types IIb, III, IV, V) and refractory hypercholesterolemias (types IIa, IIb).
    • The drug's benefits in reducing cardiovascular events must be weighed against the risk of gallstone formation.
    • This review informs clinical practice regarding the appropriate use of clofibrate in managing complex lipid disorders.

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