Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of indomethacin on renal function during different levels of surgical stress

G Kövér, K Szemerédi, H Tost

    Acta Physiologica Academiae Scientiarum Hungaricae
    |January 1, 1982
    PubMed
    Summary

    Renal prostaglandins help maintain renal blood flow during stress. Inhibiting them reduces blood flow and kidney function, especially under severe surgical stress.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Associations of preterm birth and neonatal stress exposure with chronic pain in adulthood - Results from the Gutenberg prematurity study.

    Journal of psychosomatic research·2024
    Same author

    PhenoBR: a model to phenotype body condition dynamics in meat sheep.

    Animal : an international journal of animal bioscience·2023
    Same author

    [Cohort studies in child and adolescent psychiatry].

    Der Nervenarzt·2020
    Same author

    [Wearables for context-triggered assessment in psychiatry].

    Der Nervenarzt·2019
    Same author

    Effects of BDNF Val<sup>66</sup>Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
    Same author

    The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2018

    Area of Science:

    • Nephrology
    • Physiology
    • Pharmacology

    Background:

    • Renal prostaglandins play a role in regulating kidney function.
    • Surgical stress can impact renal hemodynamics and excretory function.

    Purpose of the Study:

    • To investigate the role of renal prostaglandins in regulating renal blood flow and excretory function during surgical stress.
    • To determine if endogenous prostaglandins counteract vasoconstrictor mechanisms activated by surgical trauma.

    Main Methods:

    • Investigated renal function in anesthetized dogs under control conditions and after indomethacin administration.
    • Dogs were subjected to minor and severe surgical stress.
    • Assessed renal hemodynamic parameters, urine output, and sodium excretion.

    Main Results:

    • Indomethacin (prostaglandin synthesis inhibitor) decreased renal blood flow and excretory function, particularly under severe stress.
    • Prostaglandin inhibition increased renal vascular resistance and reduced renal blood flow during severe surgical stress.
    • The diuretic and natriuretic response to volume expansion was significantly blunted after indomethacin, especially in severely stressed dogs.

    Conclusions:

    • Endogenous prostaglandins are crucial for maintaining renal blood flow during surgical stress, but not glomerular filtration rate.
    • Renal prostaglandins counteract vasoconstrictor mechanisms activated during severe surgical trauma.
    • The data do not support a direct role for prostaglandins in regulating tubular function.

    Related Experiment Videos