Microenvironments controlling the transdifferentiation of vertebrate pigmented epithelial cells in in vitro culture

The transdifferentiation of pigmented epithelial cells in vitro is briefly introduced. Several environmental conditions regulating the process have been demonstrated experimentally. On the basis of these data we have suggested regulatory factors in relation to the mechanisms for the initiation of the transdifferentiation of pigmented epithelial cells, focussing particularly on cell surface functions. Finally, we have presented data which contributes to the establishment of a useful and powerful cell culture system which makes it possible for us to analyse the molecular basis of transdifferentiation.