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Sorbent-filled hollow fibers for hemopurification
Transactions - American Society for Artificial Internal Organs
|January 1, 1978
Summary
Researchers developed novel hemosorption devices using filled hollow fibers for kidney disease treatment. These devices, incorporating activated carbon and synthetic zeolites, show promise for removing nitrogenous waste more effectively than current dialysis methods.
Area of Science:
- Biomaterials science
- Chemical engineering
- Nephrology
Background:
- Hemosorption is a promising alternative or supplement to dialysis for treating kidney failure.
- Current hemosorption materials face limitations in efficiency and specificity for removing nitrogenous waste metabolites.
Purpose of the Study:
- To evaluate the efficacy of filled hollow fibers as hemosorption devices.
- To assess the performance of various filler materials, including activated carbon, urease-carbon, and synthetic zeolites, for removing nitrogenous waste.
Main Methods:
- Preparation of cellulose acetate hollow fibers filled with powdered activated carbon, urease-carbon, and ion exchange resins.
- Testing of zirconium phosphate and synthetic zeolites for ammonium ion adsorption.
- Evaluation of oxystarch and its derivatives for urea adsorption.
Main Results:
- Carbon-filled hollow fibers demonstrated superior mass transfer properties compared to solid-form encapsulated carbon.
- Synthetic zeolites exhibited higher specificity and capacity for ammonium ion adsorption than zirconium phosphate.
- Oxystarch and its derivatives were found unsuitable for direct urea adsorption.
Conclusions:
- Hemosorption devices utilizing urease, carbon, and zeolites hold potential for comprehensive removal of nitrogenous waste metabolites.
- These advanced materials could offer an alternative to traditional dialysis treatments.
- Further development is needed to optimize hemosorption technology for clinical application.