Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Is dipyridamole an angiogenic agent?

W Jakob, J Zipper, S B Sávoly

Experimental Pathology

|January 1, 1982

Summary

Dipyridamole did not directly stimulate endothelial cell proliferation or migration in vitro. Vascular responses observed in vivo were attributed to the preparation

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial.

Neurological research and practice·2020

Same author

Development and validation of a semi-automated surveillance system-lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019

Same author

25 years of quinacrine sterilization experience in Chile: review of 2,592 cases.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2018

Same author

Quinacrine sterilization: a retrospective.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2018

Same author

Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development.

European journal of ophthalmology·2017

Same author

Properties of AtT-20 cells in serum-reduced medium.

In vitro cellular & developmental biology. Animal·2016

Area of Science:

Cardiovascular research
Endothelial cell biology
Angiogenesis research

Background:

Dipyridamole, a nucleoside transport inhibitor, was previously reported to stimulate endothelial cell proliferation in rats.
The direct angiogenic potential of dipyridamole requires further investigation.

Purpose of the Study:

To investigate the direct effects of dipyridamole on endothelial cell proliferation and migration in vitro.
To evaluate the angiogenic potential of dipyridamole using the chorioallantoic membrane (CAM) model.

Main Methods:

Cultured calf aortic endothelial cells were used to assess proliferation and migration.
The chorioallantoic membrane (CAM) model was employed to observe vascular responses to dipyridamole and its pharmaceutical preparation, Curantyl.
pH levels were manipulated to determine their influence on observed vascular effects.

Main Results:

Dipyridamole did not directly stimulate the proliferation or migration of cultured calf aortic endothelial cells.
The pharmaceutical preparation Curantyl induced vascular responses in the CAM model.
These vascular responses were dependent on the low pH of the Curantyl preparation and could be abolished by increasing the pH.

Conclusions:

Dipyridamole does not appear to directly stimulate endothelial cell proliferation or migration.
The observed vascular effects of Curantyl in the CAM model are likely due to its acidic nature, not a direct angiogenic effect of dipyridamole.
Further research is needed to clarify the in vivo angiogenic effects of dipyridamole.

Related Experiment Videos