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Enflurane hepatitis

R J Masone, J P Goldfarb, N C Manzione

    Journal of Clinical Gastroenterology
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Enflurane, a general anesthetic, can cause liver damage (hepatitis) in some patients. This case report supports previous findings linking enflurane exposure to hepatocellular injury.

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    Area of Science:

    • Anesthesiology
    • Hepatology
    • Toxicology

    Background:

    • Halothane, a previous general anesthetic, was linked to hepatocellular damage.
    • Enflurane (ethrane; 2-chloro-1,2,2-trifluoroethyl difluoromethyl ether) emerged as a safer alternative.
    • Hepatitis following enflurane exposure has been reported in several case studies.

    Observation:

    • This paper details an additional case of enflurane-induced hepatitis.
    • The case presentation supports the existence of this adverse drug reaction.
    • The study reviews potential mechanisms behind enflurane's hepatotoxicity.

    Findings:

    • Enflurane exposure can lead to clinically significant liver injury.
    • Hepatitis is a potential, albeit rare, complication of enflurane anesthesia.

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  • The mechanism of enflurane hepatotoxicity requires further investigation.

    • Implications:

    • Clinicians should be aware of the risk of enflurane hepatitis.
    • Enflurane's safety profile may be less favorable than initially perceived.
    • Further research is needed to elucidate the pathophysiology of anesthetic-induced liver injury.