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[Sorption decholesterolization of the blood]
Insights
Haemosorption using activated carbon effectively removes toxic metabolites and cholesterol from the blood. This method shows promise for controlling hypercholesterolemia and its complications, such as atherosclerosis.
Area of Science:
- Medical Science
- Biochemistry
Context:
- Liver diseases often involve toxic metabolite accumulation.
- Hypercholesterolemia is a key risk factor for atherosclerosis.
Purpose:
- To evaluate haemosorption with activated carbon for liver disease patients.
- To investigate cholesterol-specific sorbents for hypercholesterolemia.
Summary:
- Haemosorption using activated carbon IGI removed toxic metabolites and significant cholesterol in liver disease patients.
- A novel metal-containing polymer sorbent reduced blood cholesterol by 50% and aortic damage by 50% in rabbits with diet-induced hypercholesterolemia.
Impact:
- Haemosorption may offer a new strategy for managing hypercholesterolemia and preventing atherosclerosis.
- Cholesterol-specific sorbents demonstrate potential for targeted lipid management.
Abstract:
Results of haemosorption with the use of activated carbon IGI in patients with different diseases of the liver are given. It is shown that along with the toxic metabolites the method serves to remove a considerable quantity of cholesterol. It is surmised that haemosorption can become an effective method of control of hypercholesterolemia in atherosclerosis and its complications. The results of stand tests of sorbents specific for cholesterol are presented. A sorbent, synthesized from a metal-containing polymer was used for haemosorption in experiments on rabbits with alimentary hypercholesterolemia. Single haemosorption lasting 30 min led to a two-fold decrease of the cholesterol level in the blood and to a two-fold decrease of the damaged area in the aorta 4 weeks after operation.