Synaptic remodelling and astrocytic hypertrophy in rat cerebral cortex from early to late adulthood

Ultrastructural observation of the molecular layer of the parietal cortex of rats, aged 3, 6, 10 and 17 months, revealed various atypical synaptic profiles besides typical synapses. The atypical synapses were frequently in the vicinity of hypertrophied astrocytic profiles, and were sometimes completely surrounded by astrocytic processes. The presynaptic terminal contained either no vesicles or a few small distorted vesicles. Vacant postsynaptic terminals were occasionally seen. The total surface area of astrocytic profiles and the numbers of atypical synapses increased significantly between 3 and 10 months. The astrocytic acquisition of degenerating terminals was repeatedly observed over this period. Since there was no decrease in total synaptic number at this age, the astrocytic phenomenon may represent a stage in a continuous cycle of synaptic loss and replacement in the normal brain. By 17 months, when total synapse numbers decrease, synaptic replacement may be less than optimal.