Clinical-ultrastructural study of thioridazine retinopathy

Advanced thioridazine retinopathy was observed clinically and histopathologically in a 61-year-old man with progressive, severe loss of vision who had received thioridazine in high dosages 18 years previously. The ocular fundi showed multiple confluent, nummular areas of hypopigmentation and choroidal atrophy posterior to the equator. Atrophy and disorganization of the photoreceptor outer segments appeared to be the initial degenerative event, followed by loss of the retinal pigment epithelium and choriocapillaris.