Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory impairment associated with chronic hypoxia

F A Huppert

    Thorax
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Chronic hypoxia, or low oxygen levels, significantly impairs memory function in patients with chronic obstructive lung disease. This memory deficit may be reversible with treatment, even in mild cases common in the elderly.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: potential involvement of multiple frontal-subcortical neuronal circuits.

    Journal of intellectual disability research : JIDR·2010
    Same author

    Parental practices predict psychological well-being in midlife: life-course associations among women in the 1946 British birth cohort.

    Psychological medicine·2009
    Same author

    WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function.

    The Cochrane database of systematic reviews·2007
    Same author

    Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England.

    Public health·2007
    Same author

    The modified CAMDEX informant interview is a valid and reliable tool for use in the diagnosis of dementia in adults with Down's syndrome.

    Journal of intellectual disability research : JIDR·2004
    Same author

    Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation.

    Psychoneuroendocrinology·2001

    Area of Science:

    • Neurology
    • Pulmonology
    • Gerontology

    Background:

    • Chronic obstructive lung disease (COPD) frequently leads to chronic hypoxia.
    • Hypoxia is known to affect cognitive functions.
    • The impact of varying degrees of hypoxia on specific cognitive domains requires further elucidation.

    Purpose of the Study:

    • To investigate the relationship between arterial oxygen tension and cognitive performance in COPD patients.
    • To determine which specific mental functions are affected by chronic hypoxia.
    • To explore potential therapeutic implications for memory impairment associated with hypoxia.

    Main Methods:

    • A cohort of patients with chronic obstructive lung disease underwent a battery of mental tests.
    • Arterial oxygen tension was measured using blood samples from earlobe.

    Related Experiment Videos

  • Scores on cognitive tests were correlated with measured oxygen tension levels.

    • Main Results:

    • A significant negative correlation was observed between hypoxia and memory test performance.
    • Other cognitive functions, such as attention and executive function, were not significantly affected by hypoxia.
    • Findings in humans mirrored previous observations in hypoxic animal models.

    Conclusions:

    • Chronic hypoxia disproportionately affects memory function in patients with COPD.
    • Treatment of chronic hypoxia, even mild forms prevalent in the elderly, may prevent or reverse memory impairment.
    • This suggests a potential strategy to mitigate age-related memory decline.