Related Experiment Video
Updated: Feb 10, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[Allergy to metal following osteosynthesis]
Metallic implants can corrode, leading to metal sensitization and increased allergy rates in patients with implant-associated infections. This suggests infections may trigger sensitization, impacting bone health.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Immunology
Context:
- Metallic implants are widely used in orthopedic surgery.
- Implant corrosion can release metal ions into surrounding tissues.
- Metal ion release may trigger immune responses, including metal sensitization.
Purpose:
- To investigate the relationship between metallic implants, metal sensitization, and bone infection.
- To determine if metal allergy causes inflammation or if infection leads to sensitization.
Summary:
- Patients with infected metallic implants show a significantly higher rate of allergy to cobalt and nickel compared to those without infection or with aseptic implants.
- The study utilized the leukocyte migration inhibition test to assess metal allergy in different patient groups.
- Findings indicate that patients with infected implants are more than twice as likely to be sensitive to tested metals.
Impact:
- Highlights a potential link between implant corrosion, metal sensitization, and infection morbidity.
- Suggests that bone infections may exacerbate metal sensitization, possibly through increased implant corrosion.
- Informs clinical practice regarding patient selection and monitoring for metallic implants.
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