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[Mast cell numbers in initial psoriasis vulgaris]
Zeitschrift Fur Hautkrankheiten
|November 1, 1978
Summary
Mast cells in the papillary body increase significantly in early and developed psoriasis lesions compared to normal skin. This increase is evident even in the earliest stages of psoriasis.
Area of Science:
- Dermatology
- Immunohistochemistry
- Histopathology
Context:
- Psoriasis is a chronic inflammatory skin condition.
- Mast cells are immune cells involved in inflammatory processes.
- Understanding early cellular changes in psoriasis is crucial for treatment.
Purpose:
- To quantify and compare mast cell density in early psoriatic lesions, fully developed psoriatic lesions, and normal skin.
- To investigate the role of mast cells in the pathogenesis of psoriasis.
Summary:
- Mast cell counts in the papillary body beneath the basal membrane were significantly different across normal skin, early psoriatic lesions, and fully developed psoriatic lesions.
- An increased number of mast cells per mm³ was observed in early psoriatic lesions compared to normal skin.
- Mast cell density was highest in fully developed psoriatic lesions, indicating a progressive increase during disease development.
Impact:
- Provides quantitative evidence for mast cell involvement in early psoriasis.
- Suggests mast cells as potential therapeutic targets for psoriasis treatment.
- Contributes to the understanding of psoriasis pathophysiology.