Aluminum absorption in the rat everted gut sac

Intestinal absorption of aluminum was studied in rat everted gut sacs. Aluminum transport and aluminum uptake in the jejunum initially rose with increasing bath aluminum concentration, but reached a plateau with high bath aluminum concentrations. The aluminum transport was inhibited by dinitrophenol, absence of glucose, and a temperature of 4 degrees C. There was no change with acute renal failure, chronic renal failure, parathyroidectomy, or parathyroid hormone injection. The aluminum absorption from the rat jejunum appears to involve an energy-dependent, carrier-mediated mechanism.