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[Tridoxin toxicity and tolerance in agricultural animals]
Veterinarno-Meditsinski Nauki
|January 1, 1982
Summary
Sulfadoxin-trimethoprim (tridoxin) and borgal demonstrate varying LD50 values across species and administration routes. Tridoxin shows good tolerance in calves, pigs, and sheep even at elevated doses.
Area of Science:
- Veterinary Pharmacology
- Toxicology
- Animal Health
Context:
- Sulfadoxin-trimethoprim combinations are widely used antibacterial agents in veterinary medicine.
- Assessing the safety and toxicity profiles of these drugs is crucial for determining appropriate dosages and preventing adverse effects in food-producing animals.
Purpose:
- To determine the median lethal dose (LD50) of tridoxin (sulfadoxin-trimethoprim) and borgal in various animal models.
- To evaluate the acute and subchronic toxicity and tolerance of tridoxin in different species, including rats, calves, pigs, sheep, and broilers.
Summary:
- LD50 values for tridoxin and borgal varied significantly based on administration route (intramuscular vs. oral) and animal species (mice, rats, broilers).
- Oral administration of tridoxin at 3-5 times the therapeutic dose for 30 days in rats caused no adverse clinical, biochemical, or histopathological changes.
- Tridoxin was well-tolerated in calves, pigs, and sheep at single intramuscular doses 3-5 times higher than therapeutic levels, with only transient local reactions observed.
Impact:
- Provides essential toxicological data for sulfadoxin-trimethoprim formulations in veterinary practice.
- Supports the safe and effective use of these antimicrobial agents in livestock, contributing to animal welfare and food safety.
- Informs regulatory assessments and clinical guidelines for antibiotic use in animal agriculture.