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Serum selenium levels in liver diseases

J Aaseth, J Alexander, Y Thomassen

Clinical Biochemistry

|December 1, 1982

Summary

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Selenium levels are significantly lower in patients with alcoholic cirrhosis and other liver diseases. This selenium deficiency correlates with lower albumin and prealbumin levels in severe liver conditions.

Area of Science:

Biochemistry
Clinical Medicine
Nutritional Science

Background:

Selenium deficiency has been implicated in the pathogenesis of alcoholic liver cirrhosis.
Serum selenium levels require further investigation across various liver disease groups.

Purpose of the Study:

To analyze serum selenium concentrations in patients with different types of liver diseases.
To investigate the relationship between serum selenium and markers of liver function.

Main Methods:

Serum selenium was determined using electrothermal atomic absorption spectrometry.
Nickel nitrate was used for thermal stabilization of selenium compounds.
A reference group of healthy Norwegian adults (n=40) was established.

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Main Results:

Healthy adults had a mean serum selenium of 1.53 +/- 0.25 mumol/l.
Patients with alcoholic cirrhosis, chronic active hepatitis, and chronic persistent hepatitis showed 40-80% lower serum selenium levels.
Decreased selenium concentrations in alcoholic cirrhosis and chronic active hepatitis correlated significantly with reduced albumin and prealbumin levels.

Conclusions:

Serum selenium levels are significantly reduced in patients with alcoholic cirrhosis, chronic active hepatitis, and chronic persistent hepatitis.
The findings suggest a potential role for selenium deficiency in the progression of these liver diseases.
Further research is warranted to explore selenium's pathogenetic role and therapeutic potential in liver disease.