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Multiple primary cancers following exposure to benzidine and beta-naphthylamine

K Morinaga, A Oshima, I Hara

    American Journal of Industrial Medicine
    |January 1, 1982
    PubMed
    Summary
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    Workers exposed to benzidine and beta-naphthylamine showed an increased risk of developing second primary cancers, particularly liver, gallbladder, and bile duct cancers. This suggests these chemicals have a pluripotential carcinogenic action.

    Area of Science:

    • Occupational Health
    • Toxicology
    • Cancer Epidemiology

    Background:

    • Benzidine and beta-naphthylamine are industrial chemicals with known carcinogenic potential.
    • Previous studies suggest a link between exposure to these chemicals and genitourinary cancers.
    • The occurrence of multiple primary cancers in exposed workers requires further investigation.

    Purpose of the Study:

    • To investigate the incidence of second primary cancers in workers exposed to benzidine and beta-naphthylamine.
    • To determine if exposure to these chemicals increases the risk of specific secondary cancers.
    • To confirm previous clinical data on the pluripotential action of these carcinogens.

    Main Methods:

    • A cohort study of 3,322 Japanese industrial workers manufacturing benzidine and beta-naphthylamine from 1950 to 1978.

    Related Experiment Videos

  • Ascertainment of second primary cancers in 244 workers who died of genitourinary cancer.
  • Comparison with a control group of 177 male bladder cancer patients from the Osaka Cancer Registry.

    • Main Results:

    • Eleven cases of histologically confirmed second primary cancers (liver, gallbladder, bile duct, large intestine, lung) were observed in the exposed cohort.
    • A statistically significant excess risk for liver, gallbladder, and bile duct cancer was found (p < 0.05).
    • No stomach cancer was observed in the study cohort, unlike the control group.

    Conclusions:

    • Findings confirm an increased occurrence of multiple primary cancers in workers exposed to benzidine/beta-naphthylamine.
    • These chemicals exhibit pluripotential action, increasing the risk for various secondary cancers.
    • Occupational exposure to benzidine and beta-naphthylamine necessitates stringent monitoring and preventive measures.