[Properties of liposomal allergens of Neisseria perflava]

Experiments on guinea-pigs were made to study the anaphylactogenic properties of neisserial allergens incorporated into phospholipid vesicles (liposomes). The anaphylactogenic activity of the liposomal allergens was found to be reduced as shown by the general anaphylactic reaction (anaphylactic shock) seen in the guinea-pigs sensitized with neisserial allergens. The effect under consideration was coupled with intense allergen accumulation by lung tissues of the sensitized guinea-pigs. It is assumed that the reduced anaphylactogenic activity is caused by allergen isolation from lung tissues by phospholipid membranes.