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Nephrotic syndrome in the elderly

S Lustig, J B Rosenfeld, M Ben-Bassat

    Israel Journal of Medical Sciences
    |October 1, 1982
    PubMed
    Summary
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    Nephrotic syndrome in older adults (over 60) often indicates serious kidney disease. Membranous nephropathy was the most common cause, with a poor prognosis for most patients.

    Area of Science:

    • Nephrology
    • Geriatric Medicine
    • Pathology

    Background:

    • Nephrotic syndrome is a complex kidney disorder.
    • Late-onset nephrotic syndrome (over 60 years) requires specific diagnostic consideration.

    Purpose of the Study:

    • To investigate the histologic diagnoses and prognosis of nephrotic syndrome in patients over 60 years of age.

    Main Methods:

    • Retrospective analysis of 31 patients over 60 years old with nephrotic syndrome.
    • Renal biopsy was performed for histologic diagnosis.

    Main Results:

    • Membranous nephropathy was the most frequent diagnosis (52%).
    • Other diagnoses included amyloidosis (16%), end-stage renal disease (13%), chronic glomerulonephritis (9%), minimal change disease (6%), and lupus nephritis (3%).

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  • The overall prognosis was poor, with high rates of mortality or end-stage renal failure.

    • Conclusions:

    • Late-onset nephrotic syndrome is associated with diverse and often severe underlying kidney pathologies.
    • Early diagnosis and management are crucial due to the generally poor prognosis in this age group.