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True hermaphroditism

G D Berkovitz, J A Rock, M D Urban

    The Johns Hopkins Medical Journal
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    True hermaphroditism, a rare disorder, involves individuals with both ovarian and testicular tissue. This study presents eleven cases, detailing endocrine evaluations and offering guidance on gender assignment for these patients.

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    Area of Science:

    • Endocrinology
    • Genetics
    • Reproductive Medicine

    Background:

    • True hermaphroditism is a rare disorder of sexual development.
    • It is characterized by the presence of both ovarian and testicular tissue within the same individual.
    • Accurate diagnosis and management are crucial for affected individuals.

    Purpose of the Study:

    • To present eleven cases of true hermaphroditism.
    • To detail the endocrine evaluation performed on recent patients.
    • To discuss the differential diagnosis and provide an approach to gender assignment.

    Main Methods:

    • Review of eleven cases of true hermaphroditism.
    • Detailed endocrine evaluation including karyotyping.
    • Hormonal assays (17-ketosteroids, gonadotropins, testosterone, dihydrotestosterone) before and after human chorionic gonadotropin stimulation.

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  • Sexual skin biopsy for androgen receptor binding and 5 alpha-reductase activity.

    • Main Results:

    • Eleven cases of true hermaphroditism were studied, with eight previously reported.
    • Recent patients underwent comprehensive endocrine assessments.
    • The study provides a framework for differential diagnosis and gender assignment.

    Conclusions:

    • True hermaphroditism requires thorough endocrine and genetic evaluation.
    • A systematic approach aids in differential diagnosis.
    • Guidance on gender assignment is essential for patient care.