Corticosteroids and lepromin sensitivity

Corticosteroids are known to influence the hypersensitivity reaction in a number of diseases involving hypersensitivity of tissues and alter the antigen antibody reactions in vivo. Corticosteroids administered in thirty tuberculoid cases for a period of 3 weeks showed negative response in the lepromin positive cases uniformly thereby proving suppression of cell mediated immunity in tuberculoid cases under the influence of corticosteroids; hence polar concept of tuberculoid type may be under question with continuous and prolonged corticosteroid therapy under necessity.