An evaluation of the mutagenic potential of 2-(2',4'-diaminophenoxy)ethanol using the micronucleus test

The micronucleus test in mice was used to investigate the mutagenic potential of 2-(2',4'-diaminophenoxy)ethanol. The test compound was administered by oral gavage to CD-1 mice (ICR derived) as 2 equal dosages of 250,500 and 1000 mg/kg bodyweight. Bone-marrow smears were examined for the presence of micronucleated cells in 2000 polychromatic erythrocytes per animal. In addition, the ratio of normochromatic to polychromatic erythrocytes was scored to provide an indication of the toxicity of the test compound to bone marrow cells. No increase in the incidence of micronucleated polychromatic erythrocytes was observed for any group dosed with 2-(2',4'-diaminophenoxy)ethanol, although evidence of bone-marrow toxicity was observed at all 3 dosages.