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[Malignant adrenal cortical tumors. 9 cases]
La Nouvelle Presse Medicale
|October 2, 1982
Summary
Malignant adrenal cortical tumors are rare, often affecting adult females and presenting with hormonal effects or palpable masses. Complete surgical excision is crucial, though prognosis remains poor with frequent metastases and limited survival even with adjuvant therapy like mitotane.
Area of Science:
- Endocrinology
- Oncology
- Radiology
Context:
- Malignant adrenal cortical tumors are rare endocrine neoplasms.
- Diagnosis and management present significant challenges due to tumor rarity and aggressive nature.
Purpose:
- To report on the clinical characteristics, diagnostic modalities, surgical management, and outcomes of malignant adrenal cortical tumors.
- To evaluate the efficacy of adjuvant therapy and identify prognostic factors.
Summary:
- Nine cases of malignant adrenal cortical tumors were analyzed, predominantly affecting adult females and often presenting as secretory tumors with hormonal effects or hypertension.
- Diagnostic imaging, including CT scans, was essential for tumor localization and staging. Complete surgical excision was performed in all cases, with 5 patients presenting hepatic metastases at surgery.
- Adjuvant therapy with Op'DDD (mitotane) was administered post-operatively in most cases. The median survival for deceased patients was 13 months, with limited long-term survival observed even with treatment.
Impact:
- Highlights the challenges in diagnosing and managing these rare tumors.
- Emphasizes the importance of multidisciplinary care, including surgical resection and potential adjuvant therapies.
- Suggests a poor prognosis for malignant adrenal cortical tumors, underscoring the need for further research into novel therapeutic strategies.