Drinking stimulation by a new angiotensin, crinia-angiotensin II, in rats and pigeons

The effects of crinia-angiotensin II on water intake and arterial blood pressure were investigated in conscious rats and pigeons. Injected by intravenous route to rats and pigeons, crinia-angiotensin II produced a hypertensive response practically identical to that induced by intravenous angiotensin II. Injected by intracerebroventricular route crinia-angiotensin II proved to be as active as angiotensin II in eliciting water intake in pigeons, while being less effective in rats. These findings, while demonstrating that naturally occurring angiotensins may be as active as angiotensin II itself in eliciting drinking, suggest that different molecular requirements must be satisfied to activate the angiotensin receptors for drinking in rats and pigeons.