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Preliminary studies on lasalocid toxicosis in cattle
Veterinary and Human Toxicology
|December 1, 1982
Summary
Lasalocid toxicosis in cattle can be fatal at high doses (100-125 mg/kg). Symptoms include tremors, rapid heart/respiration rates, anorexia, diarrhea, and delayed cardiac effects.
Area of Science:
- Veterinary Pharmacology
- Animal Toxicology
- Ruminant Health
Background:
- Polyether antibiotics are increasingly utilized in feedlot cattle operations.
- Lasalocid is an investigational antibiotic within this class.
Purpose of the Study:
- To investigate the toxicological effects of Lasalocid in cattle.
- To determine the dose-dependent toxicity and clinical signs associated with Lasalocid administration.
Main Methods:
- Oral administration of Lasalocid at escalating doses (25, 50, 75, 100, 125 mg/kg) to six cattle.
- Clinical observation and recording of toxicosis signs, including mortality.
Main Results:
- Lethal effects were observed at 100 and 125 mg/kg body weight.
- Clinical signs included muscle tremors, elevated heart and respiration rates, anorexia, and severe diarrhea.
- Cardiac effects were noted 7-10 days post-administration.
Conclusions:
- Lasalocid exhibits dose-dependent toxicity in cattle.
- High doses of Lasalocid can lead to fatal outcomes and significant physiological disturbances, including cardiac issues.