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Related Experiment Videos

Theophylline toxicity in a neonate

V F Larcher, H R Gamsu, M C Sanderson

    Archives of Disease in Childhood
    |September 1, 1978
    PubMed
    Summary

    Theophylline treatment for apnea in preterm infants can cause hyperglycemia and glycosuria. Careful monitoring is essential for neonates receiving theophylline.

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    Area of Science:

    • Neonatal Medicine
    • Pharmacology
    • Pediatric Endocrinology

    Background:

    • Preterm infants often experience apnea of prematurity.
    • Theophylline is a common treatment for apnea of prematurity.
    • Neonates are susceptible to metabolic disturbances.

    Observation:

    • One twin in a pair of preterm twins received theophylline at 2 mg/kg per day for apnea.
    • This twin subsequently developed episodes of hyperglycemia.
    • Glycosuria was also observed concurrently.

    Findings:

    • Theophylline administration was associated with hyperglycemia in a preterm infant.
    • Theophylline treatment led to glycosuria, indicating impaired glucose regulation.
    • This suggests a potential adverse effect of theophylline on glucose metabolism in neonates.

    Implications:

    • Neonates treated with theophylline require vigilant monitoring for hyperglycemia and glycosuria.
    • This finding highlights the importance of assessing glucose metabolism in preterm infants receiving theophylline.
    • Further research may be warranted to elucidate the mechanism of theophylline-induced hyperglycemia.

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