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Phencyclidine concentrations in postmortem body fluids and tissues

R D Budd, Y Liu

    Journal of Toxicology. Clinical Toxicology
    |October 1, 1982
    PubMed
    Summary
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    This study analyzed phencyclidine (PCP) levels in Los Angeles County victims. Higher PCP concentrations were detected in organs compared to blood, indicating widespread distribution after use.

    Area of Science:

    • Forensic Toxicology
    • Pharmacokinetics
    • Public Health

    Background:

    • Phencyclidine (PCP) is a dissociative drug with significant public health implications.
    • Understanding PCP distribution in the body is crucial for forensic investigations and clinical toxicology.

    Observation:

    • This study examined PCP concentrations in biological samples from deceased individuals in Los Angeles County.
    • Victims included in the study had deaths attributed to PCP use.

    Findings:

    • PCP blood concentrations typically ranged from 0.01 to 0.9 micrograms/mL.
    • Significantly higher PCP concentrations were observed in post-mortem tissues, including the liver, urine, bile, brain, and kidney.

    Implications:

    Related Experiment Videos

  • These findings highlight the importance of analyzing multiple biological matrices for PCP detection in post-mortem cases.
  • Understanding tissue distribution patterns can aid in determining cause of death and assessing PCP exposure levels.